Experimental Parasitology

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Singer M, Simon K, Forné I, Meissner M.;  A central CRMP complex essential for invasion in Toxoplasma gondii
In: PLOS Biology 2023; https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001937


Li W, Grech J, Stortz JF,  Gow M,  Periz J,  Meissner M and Jimenez-Ruiz E; A splitCas9 phenotypic screen in Toxoplasma gondii identifies proteins involved in host cell egress and invasion.
Nat Microbiol (2022). https://doi.org/10.1038/s41564-022-01114-y


Venugopal K, Chehade S, Werkmeister E, Barois N, Periz J, Lafont F, Tardieux I, Khalife J, Langsley G, Meissner M and Marion S.; Rab11A regulates dense granule transport and secretion during Toxoplasma gondii invasion of host cells and parasite replication. PLoS Pathog. 2020 May 28;16(5):e1008106.  doi: 10.1371/journal.ppat.1008106. eCollection 2020 May. PMID: 32463830 Free PMC article.

Spielmann T, Gras S, Sabitzki R, Meissner M.; Endocytosis in Plasmodium and Toxoplasma Parasites. Trends Parasitol. 2020, Jun;36(6):520-532. doi: 10.1016/j.pt.2020.03.010. Epub 2020 Apr 24. PMID: 32340866 Review.


Del Rosario M, Periz J, Pavlou G, Lyth O, Latorre-Barragan F, Das S, Pall GS, Stortz JF, Lemgruber L, Whitelaw JA, Baum J, Tardieux I, Meissner M.; Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion. EMBO Rep. 2019 Dec 5;20(12):e48896. doi: 10.15252/embr.201948896. Epub 2019 Oct 4. PMID: 31584242 Free PMC article.

Periz J, Del Rosario M, McStea A, Gras S, Loney C, Wang L, Martin-Fernandez ML, Meissner M.; A highly dynamic F-actin network regulates transport and recycling of micronemes in Toxoplasma gondii vacuoles. Nat Commun. 2019 Sep 13;10(1):4183. doi: 10.1038/s41467-019-12136-2. PMID: 31519913 Free PMC article.

Gras S, Jimenez-Ruiz E,  Klinger CM, Schneider K, Klingl A,  Lemgruber L,  Meissner M.;  An endocytic-secretory cycle participates in Toxoplasma gondii in motility. In: PLOS Biology 2019

Melatti C, Pieperhoff M, Lemgruber L, Pohl E, Sheiner L and Meissner M;  A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii. 2019, PLoS Pathog 15(4): e1007512.; doi.org/10.1371/journal.ppat.1007512

Stortz JF, Del Rosario M, Singer M, Wilkes JM, Meissner M, Das S.; Formin-2 drives polymerisation of actin filaments enabling segregation of apicoplasts and cytokinesis in Plasmodium falciparum. eLife 2019;8:e49030.; doi: 10.7554/eLife.49030


Morlon-Guyot J, Berry L, Sauquet I, Singh Pall G, El Hajj H, Meissner M, Daher W.; Conditional knock-down of a novel coccidian protein leads to the formation of aberrant apical organelles and abrogates mature rhoptry positioning in Toxoplasma gondii.  Mol Biochem Parasitol. 2018 Jul;223:19-30. doi: 10.1016/j.molbiopara.2018.06.003. Epub 2018 Jun 27. PMID: 29958928

Morlon-Guyot J, El Hajj H, Martin K, Fois A, Carrillo A, Berry L, Burchmore R, Meissner M, Lebrun M, Daher W.; A proteomic analysis unravels novel CORVET and HOPS proteins involved in Toxoplasma gondii secretory organelles biogenesis. Cell Microbiol. 2018 Nov;20(11):e12870. doi: 10.1111/cmi.12870. Epub 2018 Jul 8. PMID: 29911335


Hassan MA, Vasquez JJ, Guo-Liang C, Meissner M, Nicolai Siegel T.; Comparative ribosome profiling uncovers a dominant role for translational control in Toxoplasma gondii. BMC Genomics. 2017 Dec 11;18(1):961. doi: 10.1186/s12864-017-4362-6. PMID: 29228904 Free PMC article.

Periz J, Whitelaw J, Harding C, Gras S, Del Rosario Minina MI, Latorre-Barragan F, Lemgruber L, Reimer MA, Insall R, Heaslip A, Meissner M.; Toxoplasma gondii F-actin forms an extensive filamentous network required for material exchange and parasite maturation.  Elife. 2017 Mar 21;6:e24119. doi: 10.7554/eLife.24119.
PMID: 28322189 Free PMC article

Das S, Lemgruber L, Tay CL, Baum J and Meissner M.;  Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development. BMC Biology, 2017. 15(1), 70. doi:10.1186/s12915-017-0406-2 PMID:28810863, PMCID:PMC5557482

Gras S, Jackson A, Woods S, Pall G, Whitelaw J, Leung JM, Ward GE, Roberts CW and Meissner M.;  Parasites lacking the micronemal protein MIC2 are deficient in surface attachment and host cell egress, but remain virulent in vivo. Wellcome Open Research, 2017, 2, 32. doi:10.12688/wellcomeopenres.11594.1; PMID:28630943;

Whitelaw JA et al.; Surface attachment, promoted by the actomyosin system of Toxoplasma gondii is important for efficient gliding motility and invasion. BMC Biology, 2017, 15, 1. doi:10.1186/s12915-016-0343-5; PMID:28100223; PMCID:PMC5242020


Bichet M, Touquet B, Gonzalez V, Florent I, Meissner M and Tardieux I.; Genetic impairment of parasite myosin motors uncovers the contribution of host cell membrane dynamics to Toxoplasma invasion forces. BMC Biology, 2016, 14, 97. (doi:10.1186/s12915-016-0316-8) (PMID:27829452) (PMCID:PMC5101828)

Jakob PH, Kehrer J, Flood P, Wiegel C, Haselmann U, Meissner M, Stelzer EHK and Reynaud EG.;  A 3-D cell culture system to study epithelia functions using microcarriers. Cytotechnology, 2016, 68(5), pp. 1813-1825. (doi:10.1007/s10616-015-9935-0) (PMID:26847791)

Jiménez Ruiz E , Morlong-Guyot J, Daher W and Meissner M.;  Vacuolar protein sorting mechanisms in apicomplexan parasites. Molecular and Biochemical Parasitology, 2016, 209(1-2), pp. 18-25
(doi:10.1016/j.molbiopara.2016.01.007) (PMID:26844642) (PMCID:PMC5154328)

Duncan SM, Myburgh E, Philipon C, Brown E, Meissner M, Brewer J and Mottram J.; Conditional gene deletion with DiCre demonstrates an essential role for CRK3 in Leishmania mexicana cell cycle regulation. Molecular Microbiology, 2016, 100(6), pp. 931-944. (doi:10.1111/mmi.13375) (PMID:26991545) (PMCID:PMC4913733)

Harding CR, Egarter S, Gow M, Jiménez Ruiz E, Ferguson DJP and Meissner M.; Gliding associated proteins play essential roles during the formation of the inner membrane complex of toxoplasma gondii. PLoS Pathogens, 2016, 12(2), e1005403. (doi:10.1371/journal.ppat.1005403) (PMID:26845335) (PMCID:PMC4742064)


Williams MJ, Alonso H, Enciso M, Egarter S, Sheiner L, Meissner M, Striepen B, Smith BJ and Tonkin CJ. (2015) Two essential light chains regulate the MyoA lever arm to promote Toxoplasma gliding motility. mBIO, 6(5), e00845-15. (doi:10.1128/mBio.00845-15) (PMID:26374117) (PMCID:PMC4600101)

Lagal V, Dinis M, Cannella D, Bargieri D, Gonzalez V, Andenmatten N, Meissner M and Tardieux I. (2015) AMA1-deficient toxoplasma gondii parasites transiently colonize mice and trigger an innate immune response that leads to long-lasting protective immunity. Infection and Immunity, 83(6), pp. 2475-2486. (doi:10.1128/IAI.02606-14) (PMID:25847964)

Pieperhoff M et al. (2015) Conditional U1 gene silencing in Toxoplasma gondii. PLoS ONE, 10(6), e0130356. (doi:10.1371/journal.pone.0130356) (PMID:26090798) (PMCID:PMC4474610)


Tang Q, Andenmatten N, Hortua Triana MA, Deng B, Meissner M, Moreno SNJ, Ballif BA and Ward GE. (2014) Calcium-dependent phosphorylation alters class XIVa myosin function in the protozoan parasite Toxoplasma gondii. Molecular Biology of the Cell, 25(17), pp. 2579-2591. (doi:10.1091/mbc.E13-11-0648)

Jimenez-Ruiz E, Wong EH, Pall GS and Meissner M. (2014) Advantages and disadvantages of conditional systems for characterization of essential genes in Toxoplasma gondii. Parasitology, 141(11), pp. 1390-1398. 24926834. (doi:10.1017/S0031182014000559)

Harding CR and Meissner M. (2014) The inner membrane complex through development of Toxoplasma gondii and Plasmodium. Cellular Microbiology, 16(5), pp. 632-641. (doi:10.1111/cmi.12285)

Egarter S, Andenmatten N, Jackson AJ, Whitelaw JA, Pall G, Black JA, Ferguson DJP, Tardieux I, Mogilner A, Meissner M. (2014) The Toxoplasma Acto-MyoA motor complex is important but not essential for gliding motility and host cell invasion. PLoS ONE, 9(3), e91819. (doi:10.1371/journal.pone.0091819)

Bargieri D, Lagal V, Andenmatten N, Tardieux I, Meissner M and Ménard R. (2014) Host cell invasion by apicomplexan parasites: the junction conundrum. PLoS Pathogens, 10(9), e1004273. (doi:10.1371/journal.ppat.1004273)


Jackson AJ, Clucas C, Mamczur NJ, Ferguson DJ and Meissner M. (2013) Toxoplasma gondii Syntaxin 6 is required for vesicular transport between endosomal-like compartments and the Golgi Complex. Traffic, 14(11), pp. 1166-1181. (doi:10.1111/tra.12102)

Collins CR, Das S, Wong, EH, Andenmatten N, Stallmach R, Hackett F, Herman JP, Muller S, Meissner M and Blackman, MJ. (2013) Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparumenables efficient gene deletion within a single asexual erythrocytic growth cycle. Molecular Microbiology, 88(4), pp. 687-701. (doi:10.1111/mmi.12206)

Andenmatten N, Egarter S, Jackson AJ, Jullien N, Herman JP and Meissner M. (2013) Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms. Nature Methods, 10, pp. 125-127. (doi:10.1038/nmeth.2301)

Bargieri DY, Andenmatten N, Lagal V, Thiberge S, Whitelaw JA, Tardieux I, Meissner M and Ménard R. (2013) Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion. Nature Communications, 4(2552), (doi:10.1038/ncomms3552)

Kremer K et al. (2013) An overexpression screen of toxoplasma gondii rab-GTPases reveals distinct transport routes to the micronemes. PLoS Pathogens, 9(3), e1003213. (doi:10.1371/journal.ppat.1003213)

Pieperhoff MS, Schmitt M, Ferguson DJP and Meissner M. (2013) The role of clathrin in post-golgi trafficking in toxoplasma gondii. PLoS ONE, 8(10), e77620. (doi:10.1371/journal.pone.0077620)

Tomavo S, Slomianny C, Meissner M and Carruthers VB. (2013) Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion. PLoS Pathogens, 9(10), e1003629. (doi:10.1371/journal.ppat.1003629)


Kudryashev M, Münter S, Lemgruber L, Montagna G, Stahlberg H, Matuschewski K, Meissner M, Cyrklaff M and Frischknecht F. (2012) Structural basis for chirality and directional motility ofPlasmodiumsporozoites. Cellular Microbiology, 14(11), pp. 1757-1768. (doi:10.1111/j.1462-5822.2012.01836.x)

Rached FB, Ndjembo-Ezougou C, Chandran S, Talabani H, Yera H, Dandavate V, Bourdoncle P, Meissner M, Tatu U and Langsley G. (2012) Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites. Biology of the Cell, 104(1), pp. 34-47. (doi:10.1111/boc.201100081)

Anderson-White B, Beck JR, Chen CT, Meissner M, Bradley PJ and Gubbels MJ. (2012) Cytoskeleton assembly in toxoplasma gondii cell division. International Review of Cell and Molecular Biology, 298, pp. 1-31. (doi:10.1016/B978-0-12-394309-5.00001-8)

Feustel SM, Meissner M and Liesenfeld O. (2012) Toxoplasma gondii and the blood-brain barrier. Virulence, 3(2), pp. 182-192. (doi:10.4161/viru.19004)

Stutz A, Kessler H, Kaschel M, Meissner M and Dalpke AH. (2012) Cell invasion and strain dependent induction of suppressor of cytokine signaling-1 by Toxoplasma gondii. Immunobiology, 217(1), pp. 28-36. (doi:10.1016/j.imbio.2011.08.008)


Lachenmaier SM, Deli MA and Meissner M. (2011) Intracellular transport of Toxoplasma gondii through the blood–brain barrier. Journal of Neuroimmunology, 232(1-2), pp. 119-130. (doi:10.1016/j.jneuroim.2010.10.029)

Tawk L et al. (2011) Phosphatidylinositol 3-monophosphate is involved in Toxoplasma apicoplast biogenesis. PLoS Pathogens, 7(2), e1001286. (doi:10.1371/journal.ppat.1001286)


Agop-Nersesian C, Egarter S, Langsley G, Foth BJ, Ferguson DJP, Meissner M and Sibley LD. (2010) Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B. PLoS Pathogens, 6(7), e1001029. (doi:10.1371/journal.ppat.1001029)


Breinich M et al. (2009) A dynamin is required for the biogenesis of secretory organelles in Toxoplasma gondii. Current Biology, 19(4), pp. 277-286. (doi:10.1016/j.cub.2009.01.039)

Dooren G, Reiff S, Tomova C, Meissner M, Humbel B and Striepen B. (2009) A novel dynamin-related protein has been recruited for apicoplast fission in Toxoplasma gondii. Current Biology, 19(4), pp. 267-276. (doi:10.1016/j.cub.2008.12.048)

Agop-Nersesian C, Naissant B, Ben Rached F, Rauch M, Kretzschmar A, Thiberge S, Menar, R, Ferguson DJP, Meissner M and Langsley G. (2009) Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis. PLoS Pathogens, 5(1), e1000270. (doi:10.1371/journal.ppat.1000270)

Meissner M and Klaus K. (2009) What new cell biology findings could bring to therapeutics: is it time for a phenome-project in Toxoplasma gondii? Memorias Do Instituto Oswaldo Cruz, 104(2), pp. 185-189. (doi:10.1590/S0074-02762009000200010)


Baum J, Gilberger TW, Frischknecht F and Meissner M. (2008) Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma. Trends in Parasitology, 24(12), pp. 557-563. (doi:10.1016/j.pt.2008.08.006)

Agop-Nersesian C, Pfahler J, Lanzer M and Meissner M. (2008) Functional expression of ribozymes in Apicomplexa: Towards exogenous control of gene expression by inducible RNA-cleavage. International Journal for Parasitology, 38(6), pp. 673-681. (doi:10.1016/j.ijpara.2007.10.015)

Langsley G, van Noort V, Carre, C, Meissner M, de Villiers EP, Bishop R and Pain A. (2008) Comparative genomics, of the Rab protein family in Apicomplexan parasites. Microbes and Infection, 10(5), pp. 462-470. (doi:10.1016/j.micinf.2008.01.017)

Kessler H, Herm-Gotz A, Hegge S, Rauch M, Soldati-Favre D, Frischknecht F and Meissner M. (2008) Microneme protein 8 - a new essential invasion factor in Toxoplasma gondii. Journal of Cell Science, 121(7), pp. 947-956. (doi:10.1242/jcs.022350)

Book Sections

Jacot D, Meissner M, Sheiner L, Soldati-Favre D and Striepen B. (2014) Genetic manipulation of toxoplasma gondii. In: Weiss, L.M. and Kim, K. (eds.) Toxoplasma Gondii. Elsevier Academic Press: Burlington, VT, pp. 577-611. ISBN 9780123965363 (doi:10.1016/B978-0-12-396481-6.00017-9)

Book Reviews

Doerig C et al. (2009) Signalling in malaria parasites the malsig consortium. Parasite-Journal De La Societe Francaise De Parasitologie, 16(3), pp. 169-182. [Book Review]